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SU-E-I-72: Modulation of Hypothalamic Connectivity by Food Ingestion.
C Huerta1,2, J Li1,2, H Wey1,2
1University of Texas Health Science Center at San Antoinio, San Antonio, TX.
Medical Physics
|May 19, 2017
Summary
Brain connectivity in the hypothalamus differs between fasting and satiated states. Specific brain regions like the inferior frontal gyrus are active during fasting, while others like the superior temporal gyrus are engaged during satiation.
Area of Science:
- Neuroscience
- Functional Magnetic Resonance Imaging (fMRI)
Background:
- Hypothalamic connectivity plays a crucial role in regulating appetite and satiety.
- Understanding these neural pathways is essential for metabolic health research.
Purpose of the Study:
- To identify and compare hypothalamic functional connectivity in lean individuals during fasting and satiated states using resting-state fMRI (rsfMRI).
Main Methods:
- rsfMRI scans were conducted on 7 healthy lean subjects.
- Hypothalamic connectivity was analyzed using seed-based correlation analysis.
- Data preprocessing included motion correction, spatial smoothing, and temporal filtering.
Main Results:
- The inferior frontal gyrus (BA 47), associated with hunger modulation, was engaged during fasting.
- The superior temporal gyrus and mid temporal gyrus, linked to food inhibition and satiation respectively, were engaged during the satiated state.
- Cerebellar activation was observed during the satiated state, potentially related to sensory monitoring.
Conclusions:
- Hypothalamic connectivity patterns exhibit distinct neural network engagement depending on the fed or fasted state.
- These findings contribute to understanding the neural basis of appetite regulation.
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