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Related Experiment Video

Updated: Mar 2, 2026

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SU-E-T-199: The Radiological Physics Center's Credentialing Dosimetry Reviews: Their Effect on Clinical Trial

A Hollan1,2,3,3,3,3, J Lowenstein1,2,3,3,3,3, H Nguyen1,2,3,3,3,3

  • 1UT MD Anderson Cancer Center, Houston, AA.

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|May 19, 2017
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Summary

The Radiological Physics Center (RPC) evaluates institutional treatment plans to ensure adherence to clinical trial guidelines, significantly reducing protocol deviations and improving patient care quality.

Keywords:
CancerDosimetryRadiation treatmentTherapeutics

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Area of Science:

  • Medical Physics
  • Radiation Oncology
  • Clinical Trials

Background:

  • Clinical trial deviations can compromise patient outcomes and data integrity.
  • Standardized quality assurance is crucial for multicenter clinical trials.

Purpose of the Study:

  • To outline the Radiological Physics Center's (RPC) methodologies for assessing institutional compliance with clinical trial protocols.
  • To demonstrate how these evaluations decrease the National Cancer Institute (NCI) clinical trial deviation rate.

Main Methods:

  • The RPC's dosimetry group employs three primary methods for evaluating institutional adherence to treatment specifications.
  • These include site-specific benchmark cases, review of prior patient cases, and rapid review of the first patient on a trial.
  • Dosimetric review involves independent dose recalculation, while clinical review assesses DVHs and contouring with radiation oncologists.

Main Results:

  • Over five years, 1366 treatment plans were reviewed across various disease sites and modalities.
  • 222 plans (16%) failed initial submission, necessitating RPC intervention.
  • Benchmark reviews identified 18% of institutions requiring intervention, potentially preventing deviations in 17% of reviewed cases.

Conclusions:

  • RPC's pre-treatment and early-treatment plan reviews effectively reduce protocol deviation rates.
  • Proactive quality assurance by the RPC enhances the reliability of NCI clinical trials.