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Published on: August 23, 2019
Identification of prognostic and subtype-specific potential miRNAs in thymoma
Jiamin Wei1,2, Zhenguo Liu3, Kaiming Wu2
1Department of Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Aim:
We performed a study to identify the role of microRNA in thymoma.
Patients & Methods:
One hundred twenty-three thymoma patients with clinical information and miRNA expression data from The Cancer Genome Atlas were included in the study. Comprehensive bioinformatics analysis was integrated in our analysis.
Results & Conclusion:
Seven miRNAs were found to be associated with overall survival (p < 0.001). Another four miRNAs were found to be associated with disease-free survival (p < 0.001). Type C thymoma can be distinguished from nontype C thymoma by miRNAs. Interestingly, seven miRNAs showed both prognostic and subtype-specific potential. Our findings suggest that miRNAs can be used for prognostic prediction and subtype stratification.
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