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MO-F-213AB-01: Improving Dose Uniformity in Patch-Field Proton Therapy Using Beam Current Modulation.
1Washington University School of Medicine, Department of Radiation Oncology, Saint Louis, MO.
Beam current modulation improves dose homogeneity in patch-field proton therapy. Optimizing beam current reduces dose non-uniformity (DNU) in patched dose distributions, mitigating hot and cold spots for better treatment.
Area of Science:
- Medical Physics
- Radiation Oncology
- Particle Therapy
Background:
- Patch-field proton therapy aims for precise dose delivery.
- Dose non-uniformity (DNU) is a challenge in combining dose distributions.
- Beam current modulation offers a potential solution for improving homogeneity.
Purpose of the Study:
- To enhance dose homogeneity in patch-field proton therapy.
- To investigate the use of beam current modulation for dose optimization.
- To reduce dose non-uniformity (DNU) in patched dose distributions.
Main Methods:
- MCNPX simulations of the Mevion S250 beamline.
- Calculation of spread-out Bragg peak (SOBP) dose distributions.
- Optimization of distal dose profiles using beam current modulation.
Main Results:
- Standard delivery showed DNU <= 10% for depths 12.5-17.5 cm, but >35% outside this range.
- Optimized distal profiles reduced DNU to <= 10% for depths >12.5 cm.
- Shallower depths (<12.5 cm) showed no improvement due to limitations in matching lateral profiles.
Conclusions:
- Optimized beam current modulation creates gradual distal dose falloff, improving homogeneity.
- This technique mitigates hot/cold spots in patched proton therapy dose distributions.
- The method is applicable to feathering and scanned beam deliveries for enhanced dose uniformity.
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