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MO-F-213AB-02: Correcting Spread-Out Bragg Peak Slope Using Time-Resolved Monte Carlo Simulations and Beam Current

P Hill¹, E Klein¹, C Bloch¹

¹Washington University School of Medicine, Department of Radiation Oncology, Saint Louis, MO.

Medical Physics

|May 19, 2017

Summary

This summary is machine-generated.

Beam current modulation effectively reduces the spread-out Bragg peak slope in proton therapy, ensuring more uniform dose delivery. This optimization improves treatment precision by minimizing dose variations within the target field.

Keywords:

Modulators Monte Carlo methods Proton therapy

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Area of Science:

Medical Physics
Radiation Oncology
Computational Dosimetry

Background:

Proton therapy offers precise dose delivery, but the spread-out Bragg peak (SOBP) can exhibit undesirable slopes.
Minimizing SOBP slope is crucial for achieving uniform dose distribution in the treatment volume.

Purpose of the Study:

To characterize the SOBP from the Mevion S250 Proton Therapy System.
To evaluate and correct the SOBP slope using beam current modulation (BCM).

Main Methods:

Monte Carlo simulations (MCNPX) of the Mevion S250 system were performed for 24 beamline configurations.
Depth-dose profiles were calculated in a water phantom, and SOBP slopes were analyzed.
An iterative algorithm was developed to determine optimal BCM profiles to minimize SOBP slope.

Main Results:

Initial SOBP slopes ranged from -1.0 to +2.0 %/cm across configurations.
Application of optimized BCM profiles reduced slopes to ±0.2 %/cm.
The algorithm efficiently calculated BCM profiles without direct measurements.

Conclusions:

Optimized BCM profiles significantly reduce SOBP slope, enhancing dose uniformity in proton therapy.
The developed algorithm is efficient and accounts for beamline complexities.
Future research will focus on optimizing distal dose profiles using this method.