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Dynamic Lung Tumor Tracking for Stereotactic Ablative Body Radiation Therapy

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SU-E-J-169: 4D-PET for Abdominal Tumor Target Volume Generation.

J Lamb¹, P Lee¹, S Jani¹

¹UCLA School of Medicine, Los Angeles, CA.

Medical Physics

|May 19, 2017

Summary

This summary is machine-generated.

Four-dimensional PET (4D-PET) imaging increases target volume delineation for upper-abdominal tumors compared to conventional PET. This technique accurately measures tumor motion, potentially enabling personalized radiation margins for improved treatment.

Keywords:

Cancer Computed tomography Image analysis Image motion analysis Medical imaging Positron emission tomography Tissues

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Area of Science:

Oncology
Medical Imaging
Radiation Therapy

Background:

Accurate target volume delineation is crucial for effective radiation therapy.
Tumor motion, particularly in the upper abdomen, poses challenges for precise targeting.
Conventional PET imaging may not fully account for respiratory-induced tumor movement.

Purpose of the Study:

To evaluate the impact of 4D-PET on target volume delineation for upper-abdominal tumors.
To compare 4D-PET delineation with conventional un-gated PET.
To assess the ability of 4D-PET to measure tumor motion.

Main Methods:

Respiratory-correlated FDG PET/CT (4D-PET) was performed on four patients with upper-abdominal tumors.
Internal Target Volumes (ITVs) were contoured on 4D-PET (using end-inhale and end-exhale phases) and un-gated PET.
Tumor motion and volumetric differences between the two methods were analyzed.

Main Results:

In two tumors with significant motion and FDG uptake, 4D-PET volumes were 21-28% larger than un-gated PET volumes.
Un-gated PET volumes were largely contained within 4D-PET volumes (93-95%).
Tumor motion, primarily superior-inferior, measured 5.6-6.4 mm, with evidence of deformation.

Conclusions:

4D-PET accurately estimates motion for FDG-avid upper-abdominal tumors.
Utilizing 4D-PET expands target volumes compared to un-gated PET in specific patient groups.
4D-PET facilitates patient-specific margins, potentially enhancing target coverage and reducing normal tissue dose.