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SU-E-J-197: A Novel Optical Interstitial Fiber Spectroscopic System for Real-Time Tissue Micro-Vascular Hemodynamics

D Zhao1,2, D Campos1,2, Y Yan1,2

  • 1University of Wisconsin - Madison, Madison, Wisconsin.

Medical Physics
|May 19, 2017
PubMed
Summary

This study introduces a new interstitial optical fiber spectroscopy system for real-time, minimally invasive monitoring of tumor blood volume and oxygen tension. The technique quantifies tissue micro-vascular hemodynamics, aiding in adaptive radiotherapy.

Keywords:
AperturesCancerFiber optic devicesHaemodynamicsOcean opticsOptical devicesOptical fibersOptical spectroscopyTransmission measurementVisible spectra

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Area of Science:

  • Biomedical Optics
  • Medical Physics
  • Cancer Research

Background:

  • Accurate monitoring of tumor hemodynamics is crucial for effective cancer therapy.
  • Current methods for assessing tumor blood volume and oxygen tension are often invasive or lack real-time quantification.
  • Diffuse optical spectroscopies offer a promising avenue for minimally invasive tissue analysis.

Purpose of the Study:

  • To demonstrate a novel interstitial optical fiber spectroscopic system for simultaneous monitoring of tumor blood volume and oxygen tension.
  • To provide real-time, minimally-invasive quantification of tissue micro-vascular hemodynamics.
  • To develop a technique applicable to adaptive radiotherapy strategies.

Main Methods:

  • An optical fiber probe utilizing diffuse optical spectroscopies with spectral fitting was developed.
  • The system employs two 200μm core diameter fibers spaced 3mm apart, protected by 21-Ga needles for tissue penetration.
  • Light delivery and collection were performed in nude mice with xenografts, with data analyzed using Monte-Carlo modeling and spectral fitting.

Main Results:

  • The optical fiber probe successfully delivered and collected light at arbitrary depths within the tumor.
  • Spectral fitting of measured transmission spectra allowed for real-time analysis of blood volume and oxygen tension.
  • The system demonstrated the capability for minimally invasive, quantitative assessment of tumor micro-vascular hemodynamics.

Conclusions:

  • A novel optical fiber spectroscopic system was developed for deeper tumor interrogation.
  • This technique has potential applications in real-time monitoring of hypoxic cell population dynamics.
  • The system could serve as an adaptive therapy metric, particularly for hypofractionated radiotherapy.