SU-E-J-184: Liver Dose Calculation for 90Y Radioembolization with PET/CT

Area of Science:

• Nuclear Medicine
• Radiotherapy Physics
• Medical Imaging

Background:

• Hepatocellular carcinoma (HCC) treatment often involves Yttrium-90 (90Y) radioembolization, but dose delivery is heterogeneous.
• Accurate dose quantification is crucial for optimizing treatment outcomes in unresectable HCC.

Purpose of the Study:

• To develop an integrated system for quantifying 3D radiation dose distribution using 90Y PET/CT imaging.
• To enable precise evaluation of delivered 90Y doses in liver tumors.

Main Methods:

• Utilized 90Y PET/CT scans acquired post-radioembolization to map activity distribution.
• Employed a convolution method with a published dose kernel to calculate radiation dose.
• Registered diagnostic CTs with PET/CT scans to define gross tumor volume (GTV) and contour clinical target volumes (CTVs).

Main Results:

• Developed a system integrated with commercial RT PACS/Review stations via DICOM.
• Achieved dose resolution of 2-4 mm, matching PET scan resolution.
• Quantified radiation dose to 95% of GTV and surrounding CTVs, with mean liver doses within 5% of clinical results.

Conclusions:

• The developed system provides quantitative, high-resolution evaluation of delivered 90Y dose for radioembolization.
• Facilitates precise dose-volume relationship assessment for radiation oncologists.
• Demonstrates a user-friendly tool for optimizing HCC treatment planning and delivery.