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Platelet function in classic migraine during attack-free periods.

C Hedman1, K Winther, J B Knudsen

  • 1Department of Clinical Pharmacology, University of Gothenburg, Sweden.

Acta Neurologica Scandinavica
|October 1, 1988
PubMed
Summary

Migraine patients show altered platelet function, specifically a reduced beta-adrenoceptor response and decreased prostacyclin metabolism. These findings suggest specific platelet pathway changes, not general malfunction, in migraine sufferers.

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Area of Science:

  • Cardiovascular Science
  • Neuroscience
  • Hematology

Background:

  • Migraine is associated with increased platelet activity and thromboembolic risk.
  • Previous research suggests potential platelet dysfunction in migraine patients.

Purpose of the Study:

  • To investigate platelet function and related parameters in individuals with classic migraine compared to healthy controls.
  • To identify specific alterations in platelet aggregation, signaling, and lipid metabolism.

Main Methods:

  • Compared 12 classic migraine subjects with 12 age- and sex-matched controls.
  • Assessed platelet aggregation, adenosine diphosphate (ADP), adenosine triphosphate (ATP), and cyclic adenosine monophosphate (cAMP) levels.
  • Measured plasma levels of cAMP, 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and thromboxane B2 (TxB2), as well as serum TxB2 and lipids.

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Main Results:

  • No significant differences in ADP- and adrenaline-induced platelet aggregation or platelet content of ADP, ATP, and cAMP.
  • Migraine platelets exhibited a decreased beta-adrenoceptor response to isoprenaline.
  • Significantly lower plasma levels of 6-keto-PGF1 alpha were observed in the migraine group.
  • Higher low-density lipoprotein (LDL)-cholesterol levels were found in migraine cases.

Conclusions:

  • Data do not support a general platelet malfunction in migraine.
  • Suggests a decreased functional capacity of platelet beta-adrenoceptors in migraine.
  • Indicates altered prostacyclin metabolism and LDL-cholesterol levels in migraine patients.