Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Quantitative Susceptibility Mapping in Skull Base Chordoma: In Silico Analysis and In Vivo Application Towards Indirect Hypoxia Assessment.

Magnetic resonance in medicine·2025
Same author

Virtual 4DCT generated from 4DMRI in gated particle therapy: phantom validation and application to lung cancer patients.

Physics in medicine and biology·2023
Same author

Migraine-Associated Common Genetic Variants Confer Greater Risk of Posterior vs. Anterior Circulation Ischemic Stroke☆.

Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association·2022
Same author

Maternal iron status in early pregnancy and DNA methylation in offspring: an epigenome-wide meta-analysis.

Clinical epigenetics·2022
Same author

Analysis of tumour microstructure estimation from conventional diffusion MRI and application to skull-base chordoma<sup></sup>.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2021
Same author

Dosimetric effect of variable rectum and sigmoid colon filling during carbon ion radiotherapy to sacral chordoma.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2021
Same journal

Correction to "On the shape of the radiation survival curve in tumor spheroids: The role of oxygen heterogeneity".

Medical physics·2026
Same journal

Multi-view constrained semi-supervised vertebra detection for 3D ultrasound spine volume.

Medical physics·2026
Same journal

Accuracy of quantitative <sup>177</sup>Lu SPECT/CT imaging: A systematic review.

Medical physics·2026
Same journal

Physics-constrained dual-domain network for CBCT reconstruction from orthogonal X-rays in gynecologic radiotherapy.

Medical physics·2026
Same journal

Decomposition-based harmonization for quantitative PET imaging across scanners and radiotracers.

Medical physics·2026
Same journal

Development and evaluation of an in vivo dose-based monitoring system for electron FLASH radiation therapy.

Medical physics·2026
See all related articles

Related Experiment Video

Updated: Mar 2, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

16.1K

WE-E-213CD-02: Gaussian Weighted Multi-Atlas Based Segmentation for Head and Neck Radiotherapy Planning.

M Peroni1,2,3,4, G C Sharp1,2,3,4, P Golland1,2,3,4

  • 1Department of Bioengineering, Politecnico di Milano, Milano, Italy.

Medical Physics
|May 19, 2017
PubMed
Summary
This summary is machine-generated.

This study presents an efficient multi-atlas segmentation strategy for head and neck IMRT planning. The developed method, using Fixed Number atlas selection and Gaussian Weighted fusion, improves segmentation accuracy and computational efficiency.

Keywords:
Computed tomographyDatabasesEyesIntensity modulated radiation therapyMedical imagingPathologyRadiation therapyTissues

More Related Videos

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

10.1K

Related Experiment Videos

Last Updated: Mar 2, 2026

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System
08:25

Radiation Planning Assistant - A Streamlined, Fully Automated Radiotherapy Treatment Planning System

Published on: April 11, 2018

16.1K
Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform
07:57

Positron Emission Tomography-based Dose Painting Radiation Therapy in a Glioblastoma Rat Model using the Small Animal Radiation Research Platform

Published on: March 24, 2022

3.3K
PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator
10:48

PET and MRI Guided Irradiation of a Glioblastoma Rat Model Using a Micro-irradiator

Published on: December 28, 2017

10.1K

Area of Science:

  • Medical Imaging
  • Radiotherapy Planning
  • Computational Anatomy

Background:

  • Accurate segmentation of organs at risk is crucial for Intensity-Modulated Radiation Therapy (IMRT) planning in head and neck cancer.
  • Manual segmentation is time-consuming and prone to inter-observer variability.
  • Multi-atlas segmentation offers a potential solution for automated and consistent contouring.

Purpose of the Study:

  • To develop and evaluate a multi-atlas segmentation strategy for head and neck IMRT planning.
  • To compare different atlas selection and image registration techniques for improved segmentation accuracy.
  • To optimize the fusion strategy for combining information from multiple atlases.

Main Methods:

  • A multi-atlas segmentation approach using pairwise demons Deformable Registration (DR) was developed.
  • Fixed Number (FN) and Thresholding (TH) atlas selection methods were compared.
  • Gaussian Weighted (GW) fusion was employed, adapted for poor soft tissue contrast.
  • The method was validated on 31 head and neck CT datasets without pre-clustering.

Main Results:

  • The Fixed Number (FN) atlas selection strategy yielded significantly higher Dice Similarity Coefficients (DSC) for most structures compared to single atlas selection.
  • Gaussian Weighted (GW) fusion was the optimal strategy for most structures, while average contouring benefited tubular structures.
  • High median DSC values were achieved: 0.86 (mandible), 0.80 (spine), 0.51 (optical nerves), 0.81 (eyes), 0.69 (parotids), and 0.79 (brainstem).

Conclusions:

  • An efficient multi-atlas segmentation algorithm for CT volumes was developed, utilizing Deformable Registration (DR) and Gaussian Weighted (GW) fusion.
  • Fixed Number (FN) atlas selection enhances computational efficiency.
  • The strategy's applicability in real clinical settings is supported by the absence of pre-clustering and specific imaging protocols in the database.