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Who gave whom hemoglobin S: The use of restriction site haplotype variation for the interpretation of the evolution of the β<sup>S</sup> -globin gene.

American journal of human biology : the official journal of the Human Biology Council·2017

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Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Using Phylogenetic Analysis to Investigate Eukaryotic Gene Origin

Published on: August 14, 2018

Phylogenies and the forces of evolution.

Frank B Livingstone¹

¹Department of Anthropology, University of Michigan, Ann Arbor, Michigan 48109.

American Journal of Human Biology : the Official Journal of the Human Biology Council

|May 19, 2017

Summary

This summary is machine-generated.

Phylogenetic trees can accurately reflect geographic distance even with stable populations and local gene flow, not just binary fission. This suggests isolation by distance models can produce similar genetic patterns.

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Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

Area of Science:

Population Genetics
Computational Biology
Human Evolution

Background:

Phylogenetic tree construction typically assumes population binary fission drives genetic variation.
Human populations often exhibit stability with local gene flow, aligning with isolation by distance models.

Purpose of the Study:

To investigate if isolation by distance models can generate phylogenetic trees comparable to those from binary fission.
To assess the correlation between genetic and geographic distances under different population models.

Main Methods:

Simulated gene frequency changes in 50 linearly arranged, stable populations over 500 generations.
Incorporated gene flow between neighboring populations.
Constructed phylogenetic trees from simulated gene frequencies using varying numbers of genetic loci.

Main Results:

With few loci, genetic and geographic distances showed low correlation.
With 40 or more loci, a perfect correlation between genetic and geographic distances was observed.
The isolation by distance model successfully simulated phylogenetic patterns.

Conclusions:

Population stability and local gene flow (isolation by distance) can produce phylogenetic trees similar to those from binary fission.
The number of genetic loci analyzed is crucial for detecting correlations between genetic and geographic distances.
This challenges the exclusive reliance on binary fission models for phylogenetic inference in certain human populations.