Commingling analysis of blood pressure in the Tecumseh community health study
M A Province1, J Keller2, M Higgins2
1Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri 63110.
Abstract:
A commingling analysis of the distribution of systolic and diastolic blood pressure was performed on measurements from 9,226 individuals living in Tecumseh, Michigan during 1962-1965. Even after correcting for skewness in the distributions, multiple normal distributions fit the data significantly better than a single normal one, suggesting some level of commingling. The exact nature of the components differed depending on the phenotype, and the number of components entertained, suggesting a possibly complex etiology, but with some definite qualitative effects. Segregation analysis under the mixed model is needed to address the nature of blood pressure in this community more definitively.
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