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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Updated: Mar 2, 2026

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
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Controlling Structure and Function of Polymeric Drug Delivery Nanoparticles Using Microfluidics.

Aman Bains1, Yimeng Cao1, Sundiata Kly1

  • 1Department of Chemistry, University of Victoria , P.O. Box 3065, Victoria, British Columbia V8W 3 V6, Canada.

Molecular Pharmaceutics
|May 19, 2017
PubMed
Summary

Researchers controlled nanoparticle structure and drug delivery using microfluidic shear processing. This method enhances paclitaxel release and anti-cancer effects for improved nanomedicine development.

Keywords:
Polymeric nanoparticlesdrug delivery

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Polymeric nanoparticles (PNPs) are crucial for drug delivery.
  • Controlling PNP structure and function is key for effective nanomedicines.
  • Current methods often lack precise control over nanoparticle characteristics.

Purpose of the Study:

  • To demonstrate control over multiscale structure and drug delivery function of paclitaxel (PAX)-loaded polycaprolactone-block-poly(ethylene oxide) (PCL-b-PEO) PNPs.
  • To investigate the impact of microfluidic flow-directed shear processing on PNP properties.
  • To establish a manufacturing platform for advanced drug delivery systems.

Main Methods:

  • Synthesis of PCL-b-PEO copolymers with varying PCL block lengths.
  • Utilizing a two-phase gas-liquid microfluidic reactor for PNP formation and processing.
  • Employing flow-directed shear processing to influence PNP size, morphology, and drug release.
  • Comparing microfluidic processing with conventional bulk preparation methods.

Main Results:

  • PNP size, morphology, and loading efficiency were dependent on PCL block length and microfluidic flow rate.
  • Flow-variable shear processing enabled control over PNP size and morphology.
  • Microfluidic processing resulted in slower PAX release times (up to 2 weeks) compared to bulk methods.
  • PNPs formed at an intermediate flow rate exhibited optimal antiproliferative effects against MCF-7 breast cancer cells.

Conclusions:

  • Microfluidic reactors with flow-directed shear processing offer a novel manufacturing platform for drug delivery PNPs.
  • This approach allows for precise multiscale structural control, leading to enhanced drug delivery functions.
  • The developed platform has the potential to enable more effective and selective nanomedicines.