Total Syntheses of Arcyriaflavin A and Calothrixin B Using 2,2'-Bisindole-3-acetic Acid Derivative as a Common Intermediate
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Updated: Mar 2, 2026

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Published on: November 9, 2019
Sungjong Lee1, Kyung-Hee Kim1, Cheol-Hong Cheon1
1Department of Chemistry, Korea University , 145 Anam-ro, Seongbuk-gu, Seoul 02841, Republic of Korea.
Abstract:
A new protocol for the synthesis of 2,2'-bisindole-3-acetic acid derivatives from aldimines derived from 2-aminocinnamic acid derivatives and indole-2-carboxaldehyde was developed via a cyanide-catalyzed imino-Stetter reaction. With this protocol, the divergent total syntheses of arcyriaflavin A, a representative indolocarbazole natural product, and calothrixin B, a representative indolo[3,2-j]phenanthridine natural product, were completed using a 2,2'-bisindole-3-acetic acid derivative as the common intermediate.
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