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Related Experiment Video

Updated: Mar 2, 2026

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Generation of High-Throughput Three-Dimensional Tumor Spheroids for Drug Screening

Published on: September 5, 2018

Three-Dimensional Cell Cultures in Drug Discovery and Development.

Ye Fang¹, Richard M Eglen²

¹1 Biochemical Technologies, Corning Research and Development Corporation, Corning Incorporated, Corning, NY, USA.

SLAS Discovery : Advancing Life Sciences R & D

|May 19, 2017

Summary

This summary is machine-generated.

Three-dimensional (3D) cell cultures, including spheroids and organoids, are revolutionizing drug discovery. These advanced models improve disease modeling and therapeutic development, enhancing efficacy and safety assessments.

Keywords:

3D bioprinting 3D cell culture disease models efficacy multicellular spheroid organoids organs-on-chips safety screening toxicity

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Last Updated: Mar 2, 2026

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Area of Science:

Biotechnology
Cell Biology
Pharmacology

Background:

Three-dimensional (3D) cell cultures are increasingly utilized to better replicate in vivo physiological conditions compared to traditional 2D methods.
These advanced culture systems are transitioning from research tools to potential therapeutic agents for various diseases.

Purpose of the Study:

To review and assess leading 3D cell culture technologies and their applications in drug discovery.
To discuss the integration of these technologies in compound identification, screening, and development processes.

Main Methods:

Review of current literature on 3D cell culture technologies.
Analysis of applications including spheroids, organoids, scaffolds, hydrogels, organs-on-chips, and 3D bioprinting.
Discussion of implementation in disease modeling, efficacy, and safety profiling.

Main Results:

3D cell culture technologies offer enhanced physiological relevance for drug discovery.
These methods facilitate improved disease modeling and prediction of therapeutic outcomes.
Diverse 3D platforms provide versatile tools for various stages of drug development.

Conclusions:

3D cell culture technologies represent a significant advancement in pharmaceutical research and development.
Their application enhances the accuracy of preclinical drug testing and therapeutic potential assessment.
Continued innovation in 3D culture systems promises to accelerate the development of novel treatments.