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Faithful and highly efficient RNA synthesis in isolated mitochondria from rat liver
P Cantatore1, P Loguercio Polosa, A Mustich
1Dipartimento di Biochimica e Biologia Molecolare, Università di Bari, Italy.
Current Genetics
|November 1, 1988
Abstract:
Isolated rat liver mitochondria in the presence of an appropriate incubation buffer are able to support DNA transcription and RNA processing in a way qualitatively and quantitatively similar to that used by intact cells. This system is also able to synthesize an RNA species of 155-175 nucleotides which probably corresponds to the 7S RNA, a type of RNA found so far only in growing cells. The role of this RNA in the mitochondrial replication and transcription processes, in relation to the cell metabolism, is discussed.