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Low plasma cyclic nucleotides in multiple sclerosis.

M Markianos1, C Sfagos

  • 1Athens University Medical School, Eginition Hospital, Greece.

European Neurology
|January 1, 1988
PubMed
Summary
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Multiple sclerosis patients in relapse show lower cyclic AMP and cyclic GMP plasma levels compared to healthy individuals. Cyclic GMP levels correlated with disability, suggesting a role in multiple sclerosis progression.

Area of Science:

  • Neuroscience
  • Biochemistry

Background:

  • Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system.
  • Alterations in intracellular signaling molecules like cyclic nucleotides may play a role in MS pathogenesis.

Purpose of the Study:

  • To investigate plasma concentrations of cyclic AMP (cAMP) and cyclic GMP (cGMP) in patients with active multiple sclerosis.
  • To explore the relationship between these nucleotide levels and clinical disability in MS patients.

Main Methods:

  • Plasma samples were collected from 26 patients with definite multiple sclerosis in relapse.
  • Plasma samples were also collected from 26 age- and sex-matched healthy controls.
  • Concentrations of cAMP and cGMP were measured using established biochemical assays.

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Main Results:

  • Patients with multiple sclerosis exhibited significantly lower plasma levels of both cAMP and cGMP compared to healthy controls.
  • A negative correlation was observed between cyclic GMP levels and the Disability Status Scale score in MS patients.

Conclusions:

  • Reduced plasma levels of cAMP and cGMP may be associated with active multiple sclerosis.
  • Cyclic GMP levels might serve as a potential biomarker for disease severity or progression in multiple sclerosis.