Related Experiment Video

Updated: Mar 2, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
08:12

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

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MicroRNA gene polymorphisms and the risk of colorectal cancer

Guo-Qiang Rong1,2, Xin-Mei Zhang3, Bo Chen1

  • 1Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China.

Oncology Letters
|May 20, 2017
PubMed

Insights

Certain microRNA (miRNA) gene variations are linked to colorectal cancer (CRC) susceptibility. Further large-scale studies are needed to confirm these findings on miRNA and CRC risk.

Area of Science:

  • Genetics
  • Oncology
  • Epidemiology

Background:

  • Colorectal cancer (CRC) remains a significant global health concern.
  • MicroRNAs (miRNAs) play crucial roles in cancer development and progression.
  • Understanding the genetic basis of CRC susceptibility is vital for prevention and early detection.

Purpose of the Study:

  • To evaluate the epidemiological significance of microRNA gene polymorphisms in relation to colorectal cancer susceptibility.
  • To systematically analyze existing data on the association between miRNA gene variations and CRC risk.

Main Methods:

  • Conducted multiple meta-analyses of published studies.
  • Assessed associations using odds ratios and 95% confidence intervals.
  • Utilized Stata 11.0 for data analysis and modified Jadad quality scores to evaluate study quality.

Main Results:

  • Identified 15 eligible studies from an initial retrieval of 38.
  • Found associations between specific miRNA gene polymorphisms (miRNA-let-7, miR-34b/c, miR-146a, miR-603, miR-149) and CRC susceptibility.
  • Observed associations for other miRNAs (miR-192a, miR-608, miR-27a) with CRC, but not specifically with susceptibility.

Conclusions:

  • Certain miRNA gene polymorphisms are associated with colorectal cancer susceptibility.
  • Some miRNAs are linked to CRC but not directly to susceptibility.
  • Limitations include a small number of available studies, necessitating larger sample-size investigations for validation.
Keywords:
colorectal cancermeta-analysismicroRNApolymorphismrisk

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