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PPARs in Neurodegenerative and Neuroinflammatory Pathways
E Benedetti1, L Cristiano1, A Antonosante1
1Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Background:
PPARs are lipid sensors activated by dietary lipids or their metabolites, mainly fatty acids and eicosanoids, that play critical roles in CNS biology, since brain has a very high lipid content and has the higher energetic metabolism in the body.
Methods:
In neurodegenerative diseases in addition to metabolic impairment, also neuroinflammation is observed and PPARs are also closely linked to inflammatory processes. Several studies have revealed a complicated relationship between the innate immune response and tissue metabolism.
Results:
In the brain, during pathological conditions, an alteration in metabolic status occurs, particularly involving glucose utilization and production, a condition which is generally related to metabolic changes.
Conclusion:
Taking into account the high expression of PPARs in the brain, this review will focus on the role of these transcription factors in CNS diseases.
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