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Chemotherapy with si-RNA and Anti-Cancer Drugs

Kamaljeet Kaur1, Goutam Rath1, Saket Chandra1

  • 1Department of Pharmaceutics, ISF College of Pharmacy, Moga, Punjab, India.

Current Drug Delivery
|May 20, 2017
PubMed
Abstract

Insights

Combining chemotherapy with small interfering RNA (siRNA) offers a promising strategy to overcome cancer drug resistance and reduce treatment duration. Nanotechnology enhances siRNA delivery, improving therapeutic outcomes for cancer patients.

Area of Science:

  • Oncology
  • Molecular Biology
  • Nanotechnology

Background:

  • Chemotherapy is a primary cancer treatment but faces limitations like multidrug resistance and side effects.
  • Multidrug resistance in tumors arises from drug efflux, apoptosis evasion, and protective mechanisms.
  • RNA interference (RNAi), particularly using small interfering RNA (siRNA), is a therapeutic strategy to silence specific genes involved in cancer progression.

Purpose of the Study:

  • To review combination approaches of siRNA with chemotherapeutics for cancer treatment.
  • To highlight the role of nanotechnology in enhancing the bioavailability and efficacy of siRNA and other therapeutics.

Main Methods:

  • Review of existing literature on combined siRNA-chemotherapy strategies.
  • Exploration of nanotechnology-based delivery systems for siRNA and chemotherapeutic agents.

Main Results:

  • Combination chemotherapy is clinically used to combat multidrug resistance.
  • siRNA requires protective carriers due to stability and size limitations, with nanotechnology offering solutions.
  • Nanotechnology-based approaches are increasingly utilized to overcome siRNA delivery challenges.

Conclusions:

  • Combining anti-cancer drugs with siRNA represents a significant therapeutic strategy.
  • This integrated approach has the potential to shorten chemotherapy duration and improve patient outcomes.
Keywords:
NanotechnologyRNAicancerclinical trialcombination therapysi-RNA

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