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Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

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Related Experiment Video

Updated: Mar 2, 2026

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Modeling Astrocytoma Pathogenesis In Vitro and In Vivo Using Cortical Astrocytes or Neural Stem Cells from Conditional, Genetically Engineered Mice

Published on: August 12, 2014

Hodotopy, neuroplasticity and diffuse gliomas.

¹Department of Neurosurgery, Gui-de-Chauliac Hospital, Montpellier University Medical Center, 80, avenue Augustin-Fliche, 34295 Montpellier, France; U1051 Laboratory, Team "Brain Plasticity, Stem Cells and Glial Tumors", Institute for Neurosciences of Montpellier, National Institute for Health and Medical Research (Inserm), Montpellier University Medical Center, 34091 Montpellier, France.

Neuro-Chirurgie

|May 20, 2017

Summary

Diffuse gliomas can be surgically resected from eloquent brain areas without permanent deficits, thanks to the brain's neuroplasticity. Understanding these adaptive mechanisms improves glioma patient outcomes and survival.

Keywords:

Awake surgery Brain hodotopy Brain mapping Functional neurooncology Glioma Neuroplasticity

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Published on: November 17, 2021

Area of Science:

Neuroscience
Oncology
Neurosurgery

Background:

Traditional neuro-oncology focuses on tumors, neglecting brain adaptation.
Diffuse gliomas interact with the brain, inducing adaptive phenomena to maintain function.
Studying brain reaction is crucial for personalized therapeutic management and optimizing the onco-functional balance.

Purpose of the Study:

To detail the mechanisms of neuroplasticity in the context of diffuse gliomas.
To explore the implications of neuroplasticity for surgical neuro-oncology.
To understand how the brain compensates for glioma growth and migration.

Main Methods:

Discussion of cerebral mapping data.
Analysis of functional outcomes in patients undergoing awake surgery for gliomas.

Main Results:

Extensive brain resections, including eloquent areas, are feasible in adult diffuse glioma patients without permanent neurological deficits.
Demonstration of the brain's capacity to compensate for tumor-induced changes.

Conclusions:

Findings support a dynamic, network-based brain organization capable of mutual compensation.
Cognitive neurosciences aid neuro-oncology, enabling strategies like multistage surgery via cerebral remapping.
Understanding neuroplasticity in a connectomal framework improves glioma patient quality of life and survival, leading to individualized functional neuro-oncology.