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Discovery, synthesis, and structure-activity relations of 3,4-dihydro-1H-spiro(naphthalene-2,2'-piperidin)-1-ones as

Toshihiro Imaeda1, Koji Ono1, Kazuo Nakai1

  • 1Pharmaceutical Research Division: Takeda Pharmaceutical Company, Ltd., 26-1, Muraokahigashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.

Bioorganic & Medicinal Chemistry
|May 20, 2017
PubMed

Keywords:
3,4-Dihydro-1H-spiro[naphthalene-2,2′-piperidin]-1-one derivativesDocking analysisH(+),K(+)-ATPasePotassium-competitive acid blockersS-Enantiomer

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