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Related Concept Videos

Chronic Kidney Disease I: Introduction01:25

Chronic Kidney Disease I: Introduction

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Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
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Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

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Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
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Chronic Kidney Disease IV: Nursing Management01:18

Chronic Kidney Disease IV: Nursing Management

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Nursing management is essential for preventing complications, maintaining stability, and improving patients' quality of life in chronic kidney disease (CKD). By using a structured approach, nurses help slow CKD progression and support effective patient care​.1. Comprehensive patient assessmentEffective management begins with nurses reviewing the patient’s medical history, and identifying key risk factors like diabetes, hypertension, and nephrotoxic drug use. Nurses assess signs of...
489
Chronic Kidney Disease II: Clinical Manifestations01:24

Chronic Kidney Disease II: Clinical Manifestations

807
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
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Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

599
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

397
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
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Related Experiment Video

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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Diabetic Kidney Disease: Challenges, Progress, and Possibilities.

Radica Z Alicic1,2, Michele T Rooney1, Katherine R Tuttle1,2,3,4,5

  • 1Providence Health Care, Spokane, Washington.

Clinical Journal of the American Society of Nephrology : CJASN
|May 20, 2017
PubMed
Summary

Diabetic kidney disease affects 40% of diabetic patients, leading to CKD and cardiovascular issues. Innovation in biomarkers, clinical trials, and therapies is crucial for better patient outcomes.

Keywords:
altered renal hemodynamicsdiabetic nephropathydiagnosisnatural historynovel therapiespathogenesisstructural changes

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Area of Science:

  • Nephrology
  • Diabetology
  • Cardiovascular Medicine

Background:

  • Diabetic kidney disease (DKD) affects 40% of diabetic patients, being a leading cause of chronic kidney disease (CKD) globally.
  • While end-stage renal disease (ESRD) is a known outcome, most patients succumb to cardiovascular diseases or infections prior to requiring kidney replacement therapy.
  • The progression of DKD involves glomerular hyperfiltration, albuminuria, declining glomerular filtration rate (GFR), and eventual ESRD, driven by metabolic changes causing glomerular hypertrophy, glomerulosclerosis, and tubulointerstitial inflammation.

Purpose of the Study:

  • To highlight the urgent need for innovation in managing diabetic kidney disease.
  • To emphasize the importance of developing new biomarkers, clinical trial endpoints, and targeted therapies.
  • To underscore the necessity of implementing best practices in clinical and community settings.

Main Methods:

  • Review of the natural history and pathophysiology of diabetic kidney disease.
  • Analysis of current therapeutic limitations and residual risks.
  • Identification of key areas for future research and clinical implementation.

Main Results:

  • Diabetic kidney disease is a major global health challenge with significant morbidity and mortality.
  • Existing therapies leave a substantial residual risk for disease onset and progression.
  • Targeting kidney-specific mechanisms like hyperfiltration, inflammation, and fibrosis is essential.

Conclusions:

  • Significant innovation is required to improve outcomes for patients with diabetic kidney disease.
  • Advancements in biomarker discovery, clinical trial design, and targeted therapeutics are critical.
  • Effective dissemination and implementation of best practices are vital for patient care.