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Cardiovascular risk factors in Chiari malformation and idiopathic intracranial hypertension

Radek Frič1,2, Are Hugo Pripp3, Per Kristian Eide1,2

  • 1Department of Neurosurgery Oslo University Hospital-Rikshospitalet Oslo Norway.

Brain and Behavior
|May 20, 2017
PubMed

Insights

Cardiovascular risk factors like diabetes mellitus (DM) and arterial hypertension (AH) are more common in patients with Chiari malformation type 1 (CMI) and idiopathic intracranial hypertension (IIH). These conditions may be linked to AH and DM.

Area of Science:

  • Neurology
  • Cardiology
  • Public Health

Background:

  • Chiari malformation type 1 (CMI) and idiopathic intracranial hypertension (IIH) involve reduced intracranial compliance due to cerebrospinal fluid (CSF) circulation issues.
  • Cardiovascular diseases are increasingly linked to disturbances in CSF circulation.

Purpose of the Study:

  • To investigate if cardiovascular risk factors are more prevalent in patients with CMI or IIH compared to the general population.

Main Methods:

  • Retrospective analysis of 48 CMI and 52 IIH patients (2003-2014) for arterial hypertension (AH), myocardial infarction (MI), angina pectoris (AP), and diabetes mellitus (DM).
  • Comparison with prevalence data from 42,461 participants in the North-Trøndelag Health Study 3 (HUNT3).

Main Results:

  • Increased prevalence of DM in male CMI and female IIH cases.
  • Increased prevalence of AH in female IIH cases.
  • Significantly higher BMI in both female and male IIH cases.
  • Extremely low prevalence of MI and AP in CMI and IIH cohorts.

Conclusions:

  • Evidence suggests a higher prevalence of DM in male CMI and female IIH patients, and AH in female IIH patients.
  • Arterial hypertension and diabetes mellitus may be potential risk factors in the pathophysiology of CMI and IIH, warranting further investigation.
Abstract

Keywords:
Chiari malformation type IHUNT 3arterial hypertensiondiabetesidiopathic intracranial hypertension

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