Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Drug Addiction and Histone Code Alterations.

Hee-Dae Kim1, Tanessa Call1, Samantha Magazu1

  • 1Department of Basic Medical Sciences, University of Arizona College of Medicine-Phoenix, Phoenix, AZ, 85004, USA.

Advances in Experimental Medicine and Biology
|May 20, 2017
PubMed
Summary

Drug abuse alters gene expression and neural plasticity through epigenetic changes like histone modifications. Targeting these epigenetic mechanisms offers potential new treatments for addiction.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A nucleus accumbens-projecting prefrontal cortex circuit underlies chronic social stress-induced depression-like behaviors.

Translational psychiatry·2026
Same author

Transcriptional Profiling of D1-MSNs Reveals SIRT1-Dependent and -Independent Responses to Chronic Social Defeat Stress.

bioRxiv : the preprint server for biology·2025
Same author

Navigating mental health in space: gut-brain axis and microbiome dynamics.

Experimental & molecular medicine·2025
Same author

Protocol for Xenium spatial transcriptomics studies using fixed frozen mouse brain sections.

STAR protocols·2024
Same author

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits.

Neural regeneration research·2024
Same author

SIRT1 Coordinates Transcriptional Regulation of Neural Activity and Modulates Depression-Like Behaviors in the Nucleus Accumbens.

Biological psychiatry·2024

Area of Science:

  • Neuroscience
  • Epigenetics
  • Molecular Biology

Background:

  • Drug abuse causes lasting changes in brain reward pathways.
  • These changes involve alterations in gene expression, synaptic function, and neural plasticity.
  • Epigenetic mechanisms, including histone modifications and DNA methylation, play a crucial role in these persistent changes.

Purpose of the Study:

  • To explore the role of histone modifications in addiction-related gene regulation.
  • To identify potential pharmacological targets for treating drug addiction.

Main Methods:

  • Review of current research on gene expression, epigenetics, and drug addiction.
  • Focus on histone-modifying enzymes and readers involved in addiction.
Keywords:
AddictionDrug of abuseEpigeneticsHistone modificationReward circuitry

Related Experiment Videos

Main Results:

  • Specific histone modifications are integral to addiction-related gene regulatory mechanisms.
  • Histone modifiers and readers are key players in these processes.

Conclusions:

  • Histone modifications are critical for encoding environmental signals in neuronal genomes.
  • Histone modifiers and readers represent promising therapeutic targets for addiction treatment.