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Clinical case: idelalisib-induced immunoglobulin flare

Jan Novak1,2, Martin Havrda3, Lubica Gaherova1

  • 1a Department of Internal Medicine and Haematology, 3rd Faculty of Medicine , Charles University in Prague, University Hospital Kralovske Vinohrady Prague , Praha , Czech Republic.

Immunopharmacology and Immunotoxicology
|May 20, 2017
PubMed

IgM flare is a transient, treatment-induced, increase of monoclonal IgM levels in lymphoplasmacytic lymphoma/Waldenström macroglobulinemia (LPL/WM) patients. Until recently this phenomenon was observed in patients treated with Cladribine and Rituximab. Here we report a case of a heavily pretreated chronic lymphocytic leukemia patient with an atypically high immunoglobulin production who developed clinically significant immunoglobulin flare following Idelalisib treatment.

Keywords:
Idelalisibchronic lymphocytic leukemiacomplicationimmunoglobulin flaretreatment

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