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Related Concept Videos

MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA in skin diseases.

Tatiana G Ruksha1, Anna V Komina1, Nadezhda V Palkina1

  • 1Department of Pathophysiology, Krasnoyarsk State Medical University, P. Zeleznyaka str. 1, 660022, Krasnoyarsk, Russian Federation.

European Journal of Dermatology : EJD
|May 20, 2017
PubMed
Summary

MicroRNAs regulate cellular processes and are key targets for disease. Research highlights their role as epigenetic modulators in skin, offering potential for dermatological therapies.

Keywords:
atopic dermatitislichen planusmicroRNApsoriasisskin diseasevitiligo

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Area of Science:

  • Molecular Biology
  • Epigenetics
  • Dermatology

Background:

  • MicroRNAs (miRNAs) are crucial regulators of gene expression, impacting cellular functions like growth, differentiation, and apoptosis.
  • miRNAs are recognized as significant biomarkers and therapeutic targets for various diseases.
  • The skin, with accessible target cells, presents a valuable model for studying miRNA functions and modulation.

Purpose of the Study:

  • To review the current research on microRNAs in dermatology.
  • To explore the role of microRNAs as epigenetic modulators in cutaneous diseases.

Main Methods:

  • Literature review of studies on microRNAs in skin biology and disease.
  • Analysis of microRNA involvement in intercellular communication pathways in the skin.

Main Results:

  • MicroRNAs play a significant role in regulating cellular processes within the skin.
  • Dysregulation of microRNAs is implicated in the pathogenesis of various skin conditions.
  • MicroRNAs offer potential as epigenetic targets for dermatological treatments.

Conclusions:

  • MicroRNAs are vital epigenetic regulators in skin homeostasis and disease.
  • Further research into microRNA modulation in the skin could lead to novel therapeutic strategies for dermatological disorders.