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Effect of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia
Gugulethu Promise Shange1, Jagidesa Moodley1, Thajasvarie Naicker1
1a Optics and Imaging Centre, Women's Health and HIV Research Unit, Nelson R. Mandela School of Medicine, College of Health Sciences, University of KwaZulu-Natal, Durban , South Africa.
Insights
In HIV-associated pre-eclampsia, vascular endothelial growth factors A, C, and D levels did not differ between groups. However, strong correlations were found between these VEGFs, suggesting immune response neutralization.
Area of Science:
- Obstetrics and Gynecology
- Immunology
- Vascular Biology
Background:
- Pre-eclampsia is a serious pregnancy complication.
- HIV infection may alter pre-eclampsia pathophysiology.
- Vascular Endothelial Growth Factors (VEGFs) play roles in vascular health and pregnancy.
Purpose of the Study:
- To quantify and correlate serum levels of VEGF-A, VEGF-C, and VEGF-D in HIV-positive and HIV-negative pregnant women with and without pre-eclampsia.
- To investigate the relationship between VEGFs in the context of HIV-associated pre-eclampsia.
Main Methods:
- Serum samples from 76 pregnant women (pre-eclamptic and normotensive, stratified by HIV status) were analyzed.
- Vascular Endothelial Growth Factor A (VEGF-A), VEGF-C, and VEGF-D levels were measured using Bio-Plex assays.
Main Results:
- No significant differences in VEGF-A, VEGF-C, or VEGF-D levels were observed between pre-eclamptic and normotensive women.
- No significant differences were found between HIV-negative and HIV-positive women.
- A strong, significant positive correlation was found between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF-D (p < 0.0001).
Conclusions:
- Significant correlations exist among VEGF-A, VEGF-C, and VEGF-D in pregnant women.
- VEGF levels do not differ in pre-eclampsia, even in the presence of HIV.
- Findings suggest a potential neutralization of the immune response in HIV-associated pre-eclampsia.
Objective:
To measure and correlate the level of vascular endothelial growth factors A, C, and D in HIV-associated pre-eclampsia.
Methods:
VEGF-A, VEGF-C, and VEGF-D were measured in serum of 76 normotensive and pre-eclamptic pregnant women stratified by HIV status using Bio-Plex.
Results:
No significant difference was shown between pre-eclamptic and normotensive and between HIV negative and positive women. A strong significant positive correlation was demonstrated between VEGF-A and VEGF-C, VEGF-A and VEGF-D, and VEGF-C and VEGF D (p < 0.0001).
Conclusion:
This study demonstrates a significant correlation between VEGF-A, VEGF-C, and VEGF-D and no difference in pre-eclamptic and normotensive pregnant women stratified by HIV status suggesting some neutralization of the immune response in HIV-associated pre-eclampsia.
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