Development of genipin-crosslinked fucoidan/chitosan-N-arginine nanogels for preventing Helicobacter infection
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Updated: Mar 2, 2026
Preparation and Characterization of SDF-1α-Chitosan-Dextran Sulfate Nanoparticles
Published on: January 22, 2015
Yu-Hsin Lin1,2, Kun-Ying Lu3, Ching-Li Tseng4
1Department of Biological Science & Technology, China Medical University, Taichung 40402, Taiwan, ROC.
Aim:
This study aims to validate the anti-Helicobacter pylori efficacy of amoxicillin-loaded nanoparticles and nanogels with pH-responsive and site-specific drug release properties against H. pylori infection.
Materials & Methods:
Genipin-crosslinked low molecular weight fucoidan/chitosan-N-arginine nanogels (FCSA) were prepared for targeted delivery of amoxicillin to the site of H. pylori infected AGS gastric epithelial cells.
Results:
The negatively charged nanogels (n-FCSA) adhered to H. pylori and exhibited pH-responsive drug release property to reduce cytotoxic effects in H. pylori infected AGS cells.
Conclusion:
These in vitro findings suggest that n-FCSA nanogels are potential carriers for H. pylori specific delivery of antibacterial agents, and provide the basis for further studies on the clinical use of the nanogels.
