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Relationships of Inflammatory Factors and Risk Factors with Different Target Organ Damage in Essential Hypertension

Chun-Lin Lai1, Jin-Ping Xing1, Xiao-Hong Liu1

  • 1Department of Cardiology, Shanxi Provincial People's Hospital, Taiyuan, Shanxi 030012, China.

Chinese Medical Journal
|May 20, 2017
PubMed

Insights

Fibrinogen, Lp-PLA2, and uric acid are key risk factors for acute coronary syndrome, stroke, and renal damage in essential hypertension patients, respectively. Understanding these links is crucial for managing cardiovascular and kidney health.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Inflammation Research

Background:

  • Atherosclerosis (AS) is an inflammatory disease with implications across cardiovascular and renal systems.
  • Inflammation is recognized as a critical factor throughout the development of AS.
  • Essential hypertension (EH) patients are at risk for target organ damage (TOD).

Purpose of the Study:

  • To investigate the associations between inflammatory factors and risk factors with TOD in EH patients.
  • To determine the clinical significance of these relationships for managing EH complications.
  • To identify specific biomarkers linked to different organ damages.

Main Methods:

  • A cohort of 294 EH patients was categorized into four groups based on TOD.
  • A control group of 48 healthy subjects was included for comparison.
  • Serum levels of Fibrinogen (Fbg), Lipoprotein-associated phospholipase A2 (Lp-PLA2), and Uric Acid (UA) were measured, alongside other biochemical parameters and risk factors.

Main Results:

  • Fibrinogen (Fbg) emerged as the most significant independent risk factor for acute coronary syndrome (ACS) (OR: 22.242).
  • Lipoprotein-associated phospholipase A2 (Lp-PLA2) was the strongest independent risk factor for stroke (OR: 13.699).
  • Uric Acid (UA) demonstrated the highest significance as an independent risk factor for renal damage (OR: 15.307).

Conclusions:

  • Fbg, Lp-PLA2, and UA are identified as the primary independent risk factors for ACS, ischemic stroke, and renal damage in EH patients, respectively.
  • These factors significantly impact the occurrence and progression of specific target organ damages in essential hypertension.
  • The findings highlight the importance of monitoring these biomarkers for risk stratification and clinical management in EH.
Abstract

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