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Updated: Mar 2, 2026

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings
Published on: November 9, 2016
[A 36-year old schizophrenic patient with paracetamol intoxication]
P Gobbe1, J F Sauvegarde2, D Royez3
1C. H. Jolimont, Service des Urgences - Site de Lobbes, Rue de la Station 25, Lobbes, Belgium.
Prompt diagnosis of paracetamol poisoning is crucial to prevent liver damage. Psychiatric symptoms in patients can delay diagnosis and treatment, highlighting the need for careful evaluation.
Area of Science:
- Toxicology
- Psychiatry
- Hepatology
Background:
- Paracetamol (acetaminophen) poisoning is a leading cause of acute liver failure.
- Prompt administration of N-acetylcysteine is vital to prevent hepatic cytolysis.
Observation:
- A case of a 36-year-old female with delusional paranoid disorder presenting with multifocal pain is reported.
- Initial clinical and biological assessments were negative for paracetamol poisoning.
- Severe acute liver failure developed within 48 hours, with diagnosis delayed by the patient's psychiatric state hindering history taking.
Findings:
- Psychiatric symptoms can mask or obscure the diagnosis of potentially lethal conditions like paracetamol poisoning.
- Delayed diagnosis in this case led to a delay in antidote administration.
Implications:
- Emergency physicians must exercise heightened vigilance when assessing psychiatric patients for potential medical emergencies.
- Thorough and repeated evaluations are essential to avoid misdiagnosis and ensure timely management of life-threatening conditions in psychiatric patients.
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