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Use of Viral Entry Assays and Molecular Docking Analysis for the Identification of Antiviral Candidates against Coxsackievirus A16
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[Kingella kingae septicemia in a patient with coxsackievirus infection]

A Huard1, G Van Fraechem2, J Gerain3

  • 1Hôpital de Braine-l'Alleud, Waterloo Service de Médecine Interne et Endocrinologie, Rue Wayez 35, Braine-l'Alleud, Belgium.

Revue Medicale De Bruxelles
|May 20, 2017
PubMed

Insights

Kingella kingae, a difficult-to-culture bacterium, causes infections like arthritis in children. This case highlights its septicemia in an adult, emphasizing improved diagnostics for this HACEK organism.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pediatrics

Background:

  • Kingella kingae is a gram-negative coccus found in oral flora, often challenging to isolate via standard culture methods.
  • It requires extended incubation periods (over 6 days) in blood cultures for detection.
  • Kingella kingae is a significant pathogen in children under 3, causing arthritis and osteomyelitis, and is part of the HACEK group implicated in native endocarditis.

Observation:

  • A case report details a young woman experiencing Kingella kingae septicemia.
  • The septicemia occurred in the context of oral lesions attributed to Coxsackie virus infection.
  • Differential diagnosis considered conditions presenting with oral lesions.

Findings:

  • Treatment with ciprofloxacin led to a complete resolution of symptoms in the reported case.
  • The article reviews existing literature on the unusual organism Kingella kingae and its clinical presentations.
  • Improvements in laboratory diagnostic methods are expected to increase the reported incidence and prevalence of Kingella kingae infections.

Implications:

  • This case underscores the importance of considering Kingella kingae in the differential diagnosis of infections, particularly in patients with oral lesions.
  • Enhanced laboratory techniques will likely reveal a greater burden of Kingella kingae infections than currently recognized.
  • Further research into the pathogenesis and diagnostics of Kingella kingae is warranted to improve patient outcomes.

Keywords:
CoxsackievirusHACEK organismsKingella kingae

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