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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

287
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
287
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

302
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
302
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism

273
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
273
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

765
As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
765
Aging01:26

Aging

913
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
913
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion01:18

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

291
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
291

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Related Experiment Video

Updated: Mar 2, 2026

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration
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[Oncogeriatrics: An update on recent advances and knowledge].

S De Breucker1

  • 1Service de Gériatrie, Hôpital Erasme, ULB, Route de Lennik 808, Bruxelles, Belgium.

Revue Medicale De Bruxelles
|May 20, 2017
PubMed
Summary

Oncogeriatrics has advanced significantly, focusing on geriatric assessment and cancer treatment for older adults. This review highlights key international and Belgian publications from the last five years.

Keywords:
Comprehensive geriatric assessmentElderlyGeriatric oncologySIOG

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Area of Science:

  • Geriatric Medicine
  • Oncology
  • Cancer Research

Background:

  • Oncogeriatrics has seen substantial growth.
  • Progress is driven by research in geriatric assessment and expert recommendations.
  • Focus includes evaluating and treating various cancers in older adults and managing geriatric syndromes.

Purpose of the Study:

  • To review significant advancements in oncogeriatrics.
  • To highlight key publications, including Belgian contributions, from the past five years.

Main Methods:

  • Literature review of oncogeriatric studies.
  • Analysis of publications from the last five years.
  • Inclusion of international and Belgian research.

Main Results:

  • Significant progress in geriatric assessment for cancer patients.
  • Development of expert recommendations for cancer evaluation and treatment in older adults.
  • Interventions for geriatric syndromes in oncology are increasingly studied.

Conclusions:

  • The field of oncogeriatrics is rapidly evolving.
  • Recent publications demonstrate a comprehensive approach to cancer care in the elderly.
  • Belgian research contributes notably to this field.