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Evaluation of endocrine and metabolic dysfunctions after hematopoietic stem cell transplantation in children: a study

Dilek Gurlek Gokcebay1, Fatih Azik1, Cengiz Bayram1

  • 1.

Journal of Pediatric Endocrinology & Metabolism : JPEM
|May 20, 2017
PubMed

Insights

Children older than 10 undergoing hematopoietic stem cell transplantation (HSCT) face higher risks of endocrine and metabolic complications. Long-term multidisciplinary follow-up is crucial for these patients.

Area of Science:

  • Pediatric Endocrinology
  • Hematology
  • Oncology

Background:

  • Endocrine organs are sensitive to high-dose chemotherapy.
  • Hematopoietic stem cell transplantation (HSCT) can lead to endocrine and metabolic issues in children.

Purpose of the Study:

  • To evaluate endocrine and metabolic complications in pediatric patients post-HSCT.
  • To identify risk factors for these complications.

Main Methods:

  • Retrospective analysis of 100 children who underwent HSCT.
  • Minimum 1-year follow-up period.
  • Data collected from April 2010 to October 2014.

Main Results:

  • Female hypogonadism (35.7%) was the most frequent endocrine dysfunction.
  • Other common issues included growth impairment (29.4%), malnutrition (27.4%), dyslipidemia (26%), and low bone mineral density (25%).
  • Children older than 10 years at HSCT had significantly higher risks of hypogonadism, metabolic syndrome, growth impairment, and malnutrition (p<0.05).

Conclusions:

  • Endocrine and metabolic dysfunctions are more common in children over 10 years old undergoing HSCT.
  • Pediatric HSCT recipients require ongoing multidisciplinary team monitoring throughout puberty and adolescence.
Abstract

Keywords:
childrenendocrinestem cell transplantation

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