Rationalizing the Right Ratios
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Updated: Mar 2, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Johannes Arp1, Pierre Stallforth1
1Junior Research Group Chemistry of Microbial Communication, Leibniz Institute for Natural Product Research and Infection Biology, HKI, Beutenbergstrasse 11a, 07745 Jena, Germany.
Abstract:
The three hydroxamate siderophores, avaroferrin, bisucaberin, and putrebactin are synthesized by the same key enzyme AvbD. Rütschlin et al. (2017) show that the ratio of these three compounds is not governed by the enzyme's substrate specificity but rather by the substrate pool. This ensures a large metabolic flexibility and adaptability to new environments.
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