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Turning the Light On in the Phenotypic Drug Discovery Black Box
1Department of Biochemical and Cellular Pharmacology, Genentech Research and Early Development, South San Francisco, CA 94112, USA.
Cell Chemical Biology
|May 20, 2017
Abstract:
In this issue, Drawnel et al. (2017) introduce the concept of a "molecular phenotype" and demonstrate how "big data" coming from gene expression profiling, combined with signaling pathway information, small-molecule chemical information, preclinical animal models, and clinical samples can empower phenotypic discovery at several critical levels.

