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The association between systemic lupus erythematosus and bipolar disorder - a big data analysis
S Tiosano1, Z Nir2, O Gendelman1
1Department of Medicine 'B', Sheba Medical Center, 52621 Tel-Hashomer, Israel; Sackler Faculty of Medicine, Tel-Aviv University, 6997801 Tel-Aviv, Israel.
Summary
Systemic lupus erythematosus (SLE) is linked to bipolar disorder (BD). This suggests autoimmune processes in the brain may contribute to BD development in SLE patients.
Area of Science:
- Immunology
- Psychiatry
- Big Data Analytics
Background:
- Systemic lupus erythematosus (SLE) is an autoimmune disease with diverse manifestations, including neuropsychiatric symptoms.
- Bipolar disorder (BD) is a chronic mood disorder characterized by episodes of depression and mania.
Purpose of the Study:
- To investigate the association between SLE and BD using big data analysis.
- To determine if SLE is an independent risk factor for BD.
Main Methods:
- Cross-sectional study comparing SLE patients with age- and sex-matched controls.
- Utilized the Clalit Health Services medical database for a large cohort.
- Employed chi-square, t-tests, and logistic regression for statistical analysis.
Main Results:
- Higher prevalence of BD in SLE patients (0.62%) compared to controls (0.26%).
- Smoking was more common in BD patients and associated with BD.
- Both SLE and smoking were independently associated with BD in multivariate analysis.
Conclusions:
- SLE is independently associated with an increased prevalence of BD.
- Autoimmune processes affecting the central nervous system in SLE may play a role in the development of BD.
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