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The uniqueness of superoxide dismutase (SOD)--why cannot most copper compounds substitute SOD in vivo?
1Department of Physical Chemistry, Hebrew University of Jerusalem, Israel.
Free Radical Research Communications
|January 1, 1988
Abstract:
It is shown that the copper zinc superoxide dismutase is unique in its ability to catalyze O2- dismutation in vivo in contrast to other copper compounds which have this feature only in vitro. The reasons for this difference are discussed in terms of kinetic and thermodynamic parameters.