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Peroxidation of phospholipids promoted by myeloperoxidase
1Department of Experimental Medicine, Pharmacia AB, Uppsala, Sweden.
Free Radical Research Communications
|January 1, 1988
Abstract:
Myeloperoxidase was found to promote peroxidation of phospholipids under acidic conditions in the presence of hydrogen peroxide and iodide ions. The peroxidation was markedly enhanced by pyrophosphate-chelated ferric iron and was inhibited by desferrioxamine and superoxide dismutase. This observation adds lipid peroxidation to the oxidative damage caused by myeloperoxidase, which is a phagocytic cell enzyme involved in phagocyte-mediated cell destruction.