Related Experiment Video
Updated: Mar 2, 2026
07:01
Direct Mouse Trauma/Burn Model of Heterotopic Ossification
Published on: August 6, 2015
10.7K
Neurological heterotopic ossification: Current understanding and future directions
Rhys D Brady1, Sandy R Shultz1, Stuart J McDonald2
1Department of Medicine, The Royal Melbourne Hospital, The University of Melbourne, VIC, 3010, Australia.
Bone
|May 21, 2017
Summary
Neurological heterotopic ossification (NHO) causes bone growth in soft tissues after brain or spinal cord injuries, leading to pain and joint issues. Research is exploring cellular events to find new treatments for this condition.
Area of Science:
- Neuroscience
- Orthopedics
- Regenerative Medicine
Background:
- Neurological heterotopic ossification (NHO) is bone formation in soft tissues after neurological conditions like brain and spinal cord injuries.
- NHO commonly affects joints (hip, knee, shoulder), causing pain, joint deformity, morbidity, and reduced quality of life.
Purpose of the Study:
- To review current understanding of NHO pathogenesis and pathobiology.
- To discuss current treatments, novel therapeutic targets, potential biomarkers, and future research directions for NHO.
Main Methods:
- Literature review of human and animal studies on NHO.
- Synthesis of information on cellular and molecular events, clinical manifestations, and therapeutic strategies.
Main Results:
- NHO pathogenesis involves complex cellular and molecular events initiated by neurological injury.
- Current treatments are limited, highlighting the need for novel therapeutic interventions.
- Several potential therapeutic targets and biomarkers have been identified.
Conclusions:
- A deeper understanding of NHO pathobiology is crucial for developing effective treatments.
- Future research should focus on translating identified targets and biomarkers into clinical applications.
- Preventing NHO formation remains a significant challenge requiring innovative therapeutic approaches.
Related Concept Videos
01:22Sutures of the Skull
13.7K
The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures.
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...
13.7K
01:15Neurogenesis and Regeneration of Nervous Tissue
1.9K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.9K