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Updated: Mar 2, 2026

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
Published on: November 11, 2022
Stretch-activated potassium currents in the heart: Focus on TREK-1 and arrhythmias
Niels Decher1, Aytug K Kiper1, Susanne Rinné1
1Institute for Physiology and Pathophysiology, AG Vegetative Physiology, Deutschhausstrasse 1-2, 35037 Marburg, Germany.
Abstract:
This review focuses on the role and the molecular candidates of the cardiac stretch-activated potassium current (SAK). The functional properties of the two-pore domain potassium (K2P) channel TREK-1, a major candidate for the cardiac SAK, are analyzed and the molecular mechanism of stretch-activation in K2P potassium channels is discussed. Furthermore, the functional modulation of TREK-1 by different cardiac interaction partners, as well as evidence for the functional role of the stretch-dependent TREK-1 and its putative subunits in the heart is reviewed. In addition, we summarize the recent evidence that TREK-1 is involved in the pathogenesis of human cardiac arrhythmias.
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