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Related Experiment Videos

Colony-stimulating factor-1 receptor (c-fms).

C J Sherr1, M F Roussel, C W Rettenmier

  • 1Department of Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.

Journal of Cellular Biochemistry
|November 1, 1988
PubMed
Summary
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Macrophage colony-stimulating factor (CSF-1) regulates mononuclear phagocyte growth and function. Viral oncogene v-fms, derived from the CSF-1 receptor gene (c-fms), drives persistent cell growth and transforms various cell types.

Area of Science:

  • Cell Biology
  • Molecular Oncology
  • Hematopoiesis

Background:

  • Macrophage colony-stimulating factor (CSF-1) is crucial for mononuclear phagocyte development and function.
  • CSF-1 signaling occurs via high-affinity receptors (CSF-1R) encoded by the c-fms proto-oncogene.
  • CSF-1R is a tyrosine kinase receptor involved in cell proliferation, survival, and differentiation.

Purpose of the Study:

  • To investigate the role of CSF-1 and its receptor in cell growth regulation.
  • To understand how alterations in the c-fms gene can lead to oncogenic transformation.
  • To explore the mechanism by which viral CSF-1 receptor (v-fms) promotes uncontrolled cell proliferation.

Main Methods:

  • Analysis of CSF-1 and its receptor (CSF-1R) function in mononuclear phagocytes.

Related Experiment Videos

  • Genetic studies involving the c-fms proto-oncogene and its viral counterpart, v-fms.
  • Investigation of tyrosine kinase activity and signaling pathways activated by CSF-1R and v-fms.

    • Main Results:

    • CSF-1 regulates proliferation, survival, and differentiation of monocytes and macrophages.
    • The CSF-1 receptor (CSF-1R) possesses intrinsic tyrosine kinase activity.
    • Viral oncogene v-fms, resulting from c-fms gene alterations, exhibits constitutive kinase activity and transforms cells independently of CSF-1.

    Conclusions:

    • CSF-1 is essential for normal macrophage biology.
    • Aberrant CSF-1R signaling, as seen with v-fms, can lead to oncogenic transformation.
    • Understanding c-fms alterations provides insights into cancer development and potential therapeutic targets.