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Related Experiment Video

Updated: Mar 2, 2026

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[Adult intramedullary gliomas].

C Campello1, F Parker2, S Slimani2

  • 1Service de neuro-oncologie, CHU La Timone, 264, rue Saint-Pierre, 13005 Marseille, France.

Neuro-Chirurgie
|May 22, 2017
PubMed
Summary
This summary is machine-generated.

Intramedullary gliomas, rare central nervous system tumors, show good outcomes with surgical resection, particularly ependymomas. Adjuvant therapies play a limited role in managing these gliomas.

Keywords:
ChemotherapyChimiothérapieChirurgieGliomes intramédullairesIntramedullary gliomasOutcomeRadiotherapyRadiothérapieSurgeryÉvolution

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Area of Science:

  • Neuro-oncology
  • Neurosurgery
  • Neuropathology

Background:

  • Intramedullary gliomas are rare, comprising less than 4% of primary central nervous system tumors.
  • Understanding their natural history and management is crucial for patient outcomes.

Purpose of the Study:

  • To assess the natural outcome and management strategies for intramedullary gliomas.
  • To evaluate prognostic factors influencing survival rates.

Main Methods:

  • Retrospective multicenter study of 332 patients diagnosed between 1984 and 2011.
  • Histopathological analysis identified tumor types: ependymomas (72%), astrocytomas (24%), mixed gliomas (2.4%), and oligodendrogliomas (1.7%).

Main Results:

  • Ependymomas, predominantly low-grade, had a 5-year survival rate of 94.5%, while astrocytomas, often high-grade, had a 76.8% survival rate.
  • Surgical resection was common for ependymomas (>80%), whereas astrocytomas were frequently biopsied (20%).
  • Pain was the most common presenting symptom; adjuvant treatments were reserved for malignant cases.

Conclusions:

  • Surgical treatment for intramedullary gliomas, especially ependymomas, is well-established.
  • Adjuvant therapies (radiotherapy, chemotherapy) have a limited role, even in infiltrative astrocytomas.