Related Experiment Video
Updated: Mar 2, 2026
12:24
A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
6.2K
The microbiome and hepatobiliary-pancreatic cancers
Kosuke Mima1, Shigeki Nakagawa1, Hiroshi Sawayama1
1Department of Gastroenterological Surgery, Graduate School of Medical Science, Kumamoto University, Kumamoto, Japan.
Cancer Letters
|May 22, 2017
Summary
The gut microbiome influences hepatobiliary and pancreatic cancers. Understanding these microbes may lead to new treatments and prevention strategies for these challenging cancers.
Area of Science:
- Microbiome research
- Cancer biology
- Immunotherapy
Background:
- The human intestinal microbiome comprises trillions of microorganisms impacting host immunity and diseases like cancer.
- Hepatobiliary and pancreatic cancers often have poor prognoses due to invasiveness, metastasis, and treatment resistance.
Purpose of the Study:
- To explore the role of the gut microbiota in the development and progression of hepatobiliary-pancreatic tumors.
- To investigate the influence of gut microbes on cancer therapies and surgical outcomes.
Main Methods:
- Review of accumulating evidence from animal models and emerging research.
- Analysis of microbial contributions to tumor development, including DNA damage and metabolite production.
- Examination of the impact of gut microbiota on chemotherapy, immunotherapy (anti-CTLA4, anti-CD274), and postoperative complications.
Main Results:
- Microbial dysbiosis can promote hepatobiliary-pancreatic tumor development via DNA damage, oncogenic pathways, and metabolites.
- Gut microbiota affects the efficacy of cancer chemotherapies and immunotherapies.
- Microbiota influences postoperative complications, tumor recurrence, and patient survival.
Conclusions:
- A deeper understanding of gut microbiota's role in hepatobiliary-pancreatic cancers is crucial.
- Targeting the gut microbiota through diet, lifestyle, or probiotics offers potential for novel prevention and treatment strategies.
More Related Videos
Related Concept Videos
01:26Diseases of the Liver and Gallbladder
2.2K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.2K
02:17The Tumor Microenvironment
8.0K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.0K
01:29Chronic Pancreatitis II: Collaborative Care
439
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
439
01:51Mechanisms of Retrovirus-induced Cancers
7.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
7.1K
01:24Chronic Pancreatitis I: Introduction
804
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
804
01:21Hepatic Portal System
6.8K
The hepatic portal system, a critical part of our circulatory framework, transports nutrient-laden, deoxygenated blood from the gastrointestinal tract and spleen to the liver. This ingenious system plays an indispensable role in maintaining our body's metabolic equilibrium.
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
At its core, the hepatic portal vein is the result of a confluence of the superior and inferior mesenteric veins along with the splenic vein. Each of these veins has a unique role. The superior mesenteric vein is...
6.8K