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The association of arachnoid cysts and focal epilepsy: Hospital based case control study

Ivan Nikolić1, Aleksandar Ristić2, Nikola Vojvodić2

  • 1MRI Center, Clinical Center of Serbia, Medical School, University of Belgrade, Serbia.

Clinical Neurology and Neurosurgery
|May 22, 2017
PubMed
Abstract

Insights

Arachnoid cysts (ACs) are more common in patients with focal epilepsy than in healthy individuals. While a direct link is rare, ACs and epilepsy may share a common origin.

Area of Science:

  • Neurology
  • Neuroimaging
  • Epileptology

Background:

  • Arachnoid cysts (ACs) are frequently observed on brain magnetic resonance imaging (MRI).
  • The relationship between ACs and neurological conditions like focal epilepsy requires further investigation.

Purpose of the Study:

  • To determine the frequency and distribution of ACs in patients diagnosed with focal epilepsy.
  • To compare AC prevalence in focal epilepsy patients versus healthy controls.
  • To explore potential associations between ACs and the electro-clinical characteristics of focal epilepsy.

Main Methods:

  • A retrospective case-control study was conducted.
  • Data from 180 patients undergoing video-electroencephalography (EEG) monitoring and 114 healthy controls were analyzed.
  • Structural MRI images and electro-clinical data were examined.

Main Results:

  • Arachnoid cysts were found in a significantly higher proportion of focal epilepsy patients (10.5%) compared to healthy controls (2.6%) (p=0.012).
  • A clear association between AC localization and epilepsy semiology or EEG findings was observed in only one nonlesional patient with a temporal cyst.

Conclusions:

  • Arachnoid cysts occur more frequently in individuals with focal epilepsy.
  • A direct, explicit association between focal epilepsy and ACs is uncommon.
  • It is hypothesized that focal epilepsy and ACs may share a common etiological basis but are distinct entities.
Keywords:
Arachnoid cystsCase control studyFocal epilepsyVideo-EEG

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