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Sclerosing Aortic and Coronary Arteritis Due to IgG4-Related Disease

Mikael Barbu1, Ulf Lindström2, Claes Nordborg3

  • 1Department of Cardiothoracic Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden.

The Annals of Thoracic Surgery
|May 22, 2017
PubMed

Insights

A 55-year-old woman

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Pathology

Background:

  • Coronary artery disease (CAD) is a common condition often treated with bypass surgery.
  • Atherosclerosis is the typical cause of CAD.

Observation:

  • Intraoperative findings revealed unexpected diffuse thickening of the aorta and coronary arteries.
  • This suggested a cause beyond typical coronary artery atherosclerosis.

Findings:

  • Histopathology and clinical evaluation confirmed IgG4-related disease (IgG4-RD).
  • IgG4-RD is a newly identified fibroinflammatory condition affecting multiple organs.

Implications:

  • IgG4-RD can mimic other conditions, leading to underdiagnosis.
  • Increased awareness is crucial for timely diagnosis and management of IgG4-RD.

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