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Updated: Mar 2, 2026
11:56
Ex Vivo Infection of Murine Epidermis with Herpes Simplex Virus Type 1
Published on: August 24, 2015
11.7K
Interindividual Spread of Herpesviruses
1Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, 61802, USA. kj4@illinois.edu.
Advances in Anatomy, Embryology, and Cell Biology
|May 22, 2017
Summary
Herpesvirus interindividual spread, crucial for virus survival, involves complex viral and cellular interactions. This review examines Marek
Area of Science:
- Virology
- Immunology
- Evolutionary Biology
Background:
- Herpesviruses exhibit high species specificity due to long-term coevolution with hosts.
- Interindividual spread (horizontal transmission) is vital for herpesvirus propagation in populations.
- Transmission involves intricate viral and cellular protein interactions during infection stages.
Purpose of the Study:
- To delineate critical steps in herpesvirus interindividual spread.
- To explore viral and cellular mechanisms governing horizontal transmission.
- To utilize the Marek's disease virus (MDV) in chickens as a model system.
Main Methods:
- Review of existing literature on herpesvirus transmission.
- Analysis of viral assembly, release, attachment, and entry processes.
- Focus on the Marek's disease virus (MDV) chicken model.
Main Results:
- Interindividual spread requires successful completion of multiple transmission stages.
- Compromise at any stage can prevent virus transmission.
- Specific viral-host interactions are shaped by cospeciation events.
Conclusions:
- Understanding herpesvirus transmission requires detailed examination of each step.
- The MDV-chicken model provides insights into conserved and unique transmission mechanisms.
- Further research into viral-host interactions is essential for controlling herpesvirus spread.
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