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A 78-year-old man with IgA kappa multiple myeloma developed unexplained skin nodules. These lesions appeared during chemotherapy for advanced disease progression.

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Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • A 78-year-old male patient had a diagnosis of IgA kappa multiple myeloma (MM), stage III-A, in 2006.
  • The patient presented with persistent disease progression, necessitating fourth-line chemotherapy.

Observation:

  • Referred to dermatology in 2012 for evaluation of erythematous skin nodules on the anterior right thorax.
  • Skin lesions were incidentally noted during hospitalization for multiple bone fractures.
  • The patient was unaware of the lesions' development and reported no associated pain, itching, or bleeding.

Findings:

  • The case highlights a rare dermatological manifestation in a patient with advanced multiple myeloma.
  • Erythematous skin nodules were observed in the context of aggressive disease and intensive chemotherapy.

Implications:

  • This case underscores the importance of dermatological surveillance in multiple myeloma patients.
  • Further investigation may be warranted to understand the specific mechanisms linking MM progression to cutaneous involvement.
  • Recognizing such skin manifestations can aid in comprehensive patient management and treatment planning.