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Updated: Mar 2, 2026
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Chromogenic In Situ Hybridization as a Tool for HPV-Related Head and Neck Cancer Diagnosis
Published on: June 14, 2019
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The IGF axis in HPV associated cancers
Adam Pickard1, Julia Durzynska2, Dennis J McCance3
1Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK; Wellcome Centre for Cell Matrix Research, University of Manchester, M13 9PL, UK.
Mutation Research. Reviews in Mutation Research
|May 23, 2017
Summary
Human papillomaviruses (HPV) hijack the insulin-like growth factor (IGF) axis, crucial for cell growth, in HPV-associated cancers. This review explores how HPV alters IGF signaling pathways in epithelial cells.
Area of Science:
- Oncology
- Virology
- Cell Biology
Background:
- Human papillomaviruses (HPV) infect stratified epithelium, impacting keratinocyte proliferation.
- Keratinocyte growth is regulated by growth factor receptors like KGFR, EGFR, and IGF receptors.
- The insulin-like growth factor (IGF) axis plays a vital role in tissue growth and development.
Purpose of the Study:
- To review the mutation, gene transcription, translation, and processing of the IGF axis in HPV-associated cancers.
- To investigate whether HPV hijacks the IGF axis for its replication and to promote cancer development.
Main Methods:
- Literature review focusing on the IGF axis in HPV-associated cancers.
- Analysis of existing data on gene expression, mutation, and protein processing related to IGF signaling in HPV infections.
Main Results:
- The IGF axis is frequently altered in HPV-associated cancers.
- Evidence suggests HPV actively manipulates IGF signaling pathways to enhance keratinocyte proliferation and survival.
- Specific components of the IGF axis show altered expression and function in the context of HPV infection.
Conclusions:
- HPV likely hijacks the IGF axis to facilitate viral replication and drive malignant transformation.
- Understanding IGF axis alterations in HPV cancers is critical for developing targeted therapies.
- Further research is needed to fully elucidate the mechanisms by which HPV interacts with the IGF axis.
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