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Related Experiment Video

Updated: Mar 2, 2026

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The IGF axis in HPV associated cancers.

Adam Pickard1, Julia Durzynska2, Dennis J McCance3

  • 1Centre for Cancer Research and Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK; Wellcome Centre for Cell Matrix Research, University of Manchester, M13 9PL, UK.

Mutation Research. Reviews in Mutation Research
|May 23, 2017
PubMed
Summary

Human papillomaviruses (HPV) hijack the insulin-like growth factor (IGF) axis, crucial for cell growth, in HPV-associated cancers. This review explores how HPV alters IGF signaling pathways in epithelial cells.

Keywords:
CancerHPVIGF-IIGF-IIIGF1RIGF2R

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A Comparative Approach to Characterize the Landscape of Host-Pathogen Protein-Protein Interactions
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Area of Science:

  • Oncology
  • Virology
  • Cell Biology

Background:

  • Human papillomaviruses (HPV) infect stratified epithelium, impacting keratinocyte proliferation.
  • Keratinocyte growth is regulated by growth factor receptors like KGFR, EGFR, and IGF receptors.
  • The insulin-like growth factor (IGF) axis plays a vital role in tissue growth and development.

Purpose of the Study:

  • To review the mutation, gene transcription, translation, and processing of the IGF axis in HPV-associated cancers.
  • To investigate whether HPV hijacks the IGF axis for its replication and to promote cancer development.

Main Methods:

  • Literature review focusing on the IGF axis in HPV-associated cancers.
  • Analysis of existing data on gene expression, mutation, and protein processing related to IGF signaling in HPV infections.

Main Results:

  • The IGF axis is frequently altered in HPV-associated cancers.
  • Evidence suggests HPV actively manipulates IGF signaling pathways to enhance keratinocyte proliferation and survival.
  • Specific components of the IGF axis show altered expression and function in the context of HPV infection.

Conclusions:

  • HPV likely hijacks the IGF axis to facilitate viral replication and drive malignant transformation.
  • Understanding IGF axis alterations in HPV cancers is critical for developing targeted therapies.
  • Further research is needed to fully elucidate the mechanisms by which HPV interacts with the IGF axis.